I see this is an old thread, but I find the ET technique to be very novel and potentially effective. The gist I get from reading Heidi's posts is that she was able to control a previously uncontrollable intake of carb/junk/addictive foods in a relatively easy manner leading to the reaching her goal weight. Typically, someone with a strong addiction to these types of foods has considerable trouble controlling their intake; me being one of the them. Hopefully this method will be as efficacious for me.
I've been doing ET for the past couple days. Thus far, it's worked to help me restrict my intake of foods (actually swallowing) to those that I consider diet-friendly (low carb/high protein/moderate fat). The real test would be to see if this holds for at least 10 days/15 lbs weight loss. Typically, I'll lose around 15 lbs (obviously mainly glycogen/water and likely some fat/muscle) within a week or two, but then the cravings kick in hardcore. If I can get past that point comfortably, I may be able to go indefinitely. I'll report back with my progress.
In doing ET, I haven't noticed a decrease in pleasure from addictive food flavors, but I just started. The effect it does seem to have is creates what feels somewhat like a cigarette buzz. Not sure if it from ET or not. It could have been from something else or just how I was feeling at the time. I'm not overly perceptive to these types of things.
One theoretical problem I'm having with ET is that it seems to the opposite of what I thought SGL was (which I believe Heidi states that ET is a sort of extension of). It seems that SGL advocates consuming calories without flavor, in which the idea originated from the study that showed saccharin produced weight gain in rats (flavor without calories). I'm probably messing up of the mechanics of all this, and being that it worked great for Heidi, it seems to have a lot of merit, but if this works, wouldn't using artificial sweeteners work as well? What about chewing sugarless gum? If the ET theory is correct, wouldn't artificial sweeteners subdue the need for carbs/sweets? Wouldn't they quickly become unappetizing (no insulin effect, etc.)? Hopefully, this can be deconflicted.
Naltrexone is also very interesting to me. I've wondered that if neurotransmitter reuptake inhibitors/agonists eventually cause downregulation in the long-term, could an antagonist allowing upregulation be more effective in the long term? Todd and I discussed this in the comments section of his receptor/set-point article. It would seem that LDN might mediate many of the risks of a higher dose.
Just a thought, but I think IF may work well with LDN and help to accelerate upregulation. Here's a potential protocol:
- Take LDN (maybe ~6 mg) a couple hours for bedtime
- Assuming it takes effect within an hour or so, wait until the effect has taken and engage in some addictive behavior you would like extinguished - i.e. a small/predetermined amount of addictive food
- sleep (hopefully the LDN will promote faster upregulation of receptors during sleep...not sure if that is the case or not as I'm not sure if they are generally actived during sleep or not)
- wake and continue fasting during working hours (hopefully adding to receptor upregulating)
- Evening: have healthy food and exercise. By this time, LDN should be mostly washed out and these actions should be reinforced (4 hour half-life])
- repeat
If LDN promotes upregulation during sleep, with the short half-life, it would allow most of the negative effects of opioid blocking to be only realized while sleeping. So when you eat 18-20 hours after dosing, you don't have to over-eat to realize satiety.
I'm not sure if 6 mg is enough to blunt the effects of addictive foods. If not, then I would attempt to avoid consuming them and ET instead. I may do that either way so to accelerate fat-loss. I'm at 260 and should be about 210 (~190 lean body mass via DEXA scan), so I have a ways to go.
If I can get my hands on some LDN, I'll give this a try.
Heidi mentioned FDA trials on Naltrexone and another drug. Here's the wikipedia link:
http://en.wikipedia.org/wiki/Bupropion/naltrexoneI think it is a bit strange they are combining naltrexone with a dopamine reuptake inhibitor. I believe that would downregulate dopamine in the long run. It seems like contradicting philosophies. Either way, I don't think the results were that impressive relative to controls. I'd be interested to see the rate of weight loss over the year and see if nal/dop is significantly better than control in the later months. That would be a better predictive of long-term weight loss.