I personally find skipping breakfast and lunch to be the most comfortable, and I've adapted to it. But sometimes I mix it up and instead skip dinner. I don't think there is a single best way to do it. Experiment and find what works best for you. Everyone has a different daily routine and one has to consider not just pure biology, but also personality, work or school appointments, and social interactions. On the fast-5 website, you'll find many different approaches. And you'll get other ideas if you go to Martin Berkhan's Leangains site -- particularly regarding the benefits of combining intermittent fasting with exericise.