Author Topic: Boost energy with anti-caffeine?  (Read 1187 times)

Offline Mercurial

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Boost energy with anti-caffeine?
« on: December 09, 2013, 08:02:04 AM »
Many (most?) people show an adaptive response to caffeine - e.g., having coffee every day makes the coffee less effective over time and eventually makes it hard to function without the regular dose. This makes me think that hormetism could apply here: maybe taking something that acts in the opposite direction of caffeine would, in essence, give you the energy of being caffeinated most of the time when the anti-caffeine isn't in your system.

Is there clear reason to think this is a bad idea? (I have some thoughts but I'd rather not anchor everyone here with them right from the start.)

If it seems on net like a good idea, what do you suppose could act as this "anti-caffeine"?

Offline Todd Becker

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Re: Boost energy with anti-caffeine?
« Reply #1 on: December 09, 2013, 10:13:38 AM »
Interesting idea, Mercurial.

Caffeine works by binding to and blocking the adenosine receptors in the brain.  Adenosine is a natural brain neurotransmitter that helps induce sleep, so blocking it promotes wakefulness.   

People who consume a lot of caffeine develop a tolerance effect.  The best way to restore sensitivity to caffeine is to withdraw for a few days and to moderate the level of consumption.    So withdrawal, in and of itself is a kind of hormetic "anti-caffeine" to some extent.

If you want to go further than that, you could look at ways to either increase adenosine levels, or perhaps upregulate adenosine receptors.  Studies show that one drug, phenylephrine, a common antihistamine decongestant known to produce drowsiness as a side effect, does exactly that:

http://ajpheart.physiology.org/content/298/2/H545

There are probably more natural ways to achieve this.  I'd also have some concerns about anything that makes you excessively drowsy.   I'll look into it further....maybe others have ideas?

Todd

Offline AnaGrey

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Re: Boost energy with anti-caffeine?
« Reply #2 on: March 09, 2015, 09:01:15 AM »
Interesting idea, Mercurial.

Caffeine works by binding to and blocking the adenosine receptors in the brain.  Adenosine is a natural brain neurotransmitter that helps induce sleep, so blocking it promotes wakefulness.   

People who consume a lot of caffeine develop a tolerance effect.  The best way to restore sensitivity to caffeine is to withdraw for a few days and to moderate the level of consumption.    So withdrawal, in and of itself is a kind of hormetic "anti-caffeine" to some extent.

If you want to go further than that, you could look at ways to either increase adenosine levels, or perhaps upregulate adenosine receptors.  Studies show that one drug, phenylephrine, a common antihistamine decongestant known to produce drowsiness as a side effect, does exactly that:

http://ajpheart.physiology.org/content/298/2/H545

There are probably more natural ways to achieve this.  I'd also have some concerns about anything that makes you excessively drowsy.   I'll look into it further....maybe others have ideas?

Todd

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